Amino Acid Uptake Assay Kit

Description

Amino acids are essential for intracellular protein and nucleic acid synthesis, Especially for cancer cells which are proliferating continually. Since the supply of acetyl CoA from the glycolytic pathway is decreased in cancer cells, they have a furthermore huge demand for amino acids which are an important nutrient source for the TCA cycle. The research has shown that cancer cells increase the expression of the amino acid transporter LAT1 (L-type amino acid transporter 1) and take up a large number of amino acids, which is expected to be a new target for anti-Cancer drugs' discovery. In immunotherapy, not only the metabolic changes in cancer cells but also in immune cells are considered to affect the treatment. For example, as senescence occurs in immune cells, their metabolic system changes, and their immune capacity to attack cancer cells decreases. Therefore, research is being conducted on nutrient uptake regulation by immune cells and improving the effectiveness of cancer immunotherapy.