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Cystine Uptake Assay Kit
Cystine Uptake Assay Kit
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Brand:
Dojindo
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Unit Price (10 ml)
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Description
Description
The cystine transporter xCT is a crucial transporter that maintains cellular redox balance by regulating glutathione synthesis via cystine uptake. xCT is highly expressed in several types of cancer cells and is expected to be a therapeutic target for cancer. Therefore, xCT has recently attracted researchers' attention as one of the targets for cancer treatment. The xCT inhibitors sulfasalazine and erastin are known to reduce intracellular glutathione levels by inhibiting cystine uptake, thereby inducing ferroptosis, a form of cell death. It is also known that immune cells highly express xCT upon activation, suggesting that intracellular redox regulation via cystine uptake is also important for immune responses.