Dextran sulfate sodium salt (8,000 (avg) Da)

Key Features and Details

Polyanionic derivative of dextran with an average of 1.9 sulfate groups per glucosyl residue
High purity and consistant quality enables its application in pharmaceuticals and biotechnology industry
Can be used as an anticoagulant, antiviral and antilipemic agent

SYNONYMS: Dextran sodium sulfate; DSS
CAS: # 9011-18-1
MOLECULAR WEIGHT: 8000 (avg) Da
MDL No: MFCD00081551
SKU 02101516-CF Categories , , , Tag

PRODUCT DESCRIPTION

Dextran Sulfate Sodium Salt (8,000 (avg) Da M.Wt) Application Notes Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used as an anticoagulant, antiviral as well as antilipemic agent.Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein. Exhibits activity as an adjuvant.Antiviral and Antienzyme Activity – Baba et al., have shown in In Vitro studies that DSS inhibits the binding of various enveloped viruses including Human Immunodeficiency Virus (HIV), Herpes Virus (HSV) and Cytomegalovirus (CMV) to cells. Additionally, DSS has also shown to exhibit a potent inhibitory effect on many enzymes, for example hyaluronidase, adenylate cyclase, and amylase. Hofer at al., have shown that DSS induces bacterial translocation in HIV-infected humanized mice. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Immunology | Antiviral | Antilipemic | Anticoagulant
SPECIFICATIONS
SKU: 02101516-CF
Base Catalog Number: 101516
Alternate Names: 101516
Boiling Point : 310 °C
CAS : # 9011-18-1
Grade : Reagent
MDL No : MFCD00081551
Melting Point : 92 °C
Molecular Weight : 8000 (avg) Da
Optical Rotation: +75 ° to 105 °
PPE : Eyeshields, Gloves, respirator filter
RTECS No : HH9290000
Solubility : >24.8 [ug/mL]
Vapor Pressure : 2.6X10-4 mm Hg at 25 deg C /Estimated/

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