2-Iminothiolane hydrochloride

Key Features and Details

2-Iminothiolane Hydrochloride

SYNONYMS: 2-Thiolanimine hydrochloride; 2IT; Dihydro-2(3H)-thiophenimine hydrochloride; Trauts reagent
CAS: # 4781-83-3
MOLECULAR WEIGHT: 137.625 g/mol
MDL No: MFCD00039013
SKU 02151319-CF Categories , , Tag


2-Iminothiolane Hydrochloride Application Notes 2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking. It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Protein modification and cross-linking reagent
SKU: 02151319-CF
Base Catalog Number: 151319
Alternate Names: 151319
Beilstein Registration No : 3620079
CAS : # 4781-83-3
Extinction Coefficient : EmM = 8.84 (0.1 M HCl)(Lit.)
Format : Powder
MDL No : MFCD00039013
Molecular Formula : C4H7NS·HCl
Molecular Weight : 137.625 g/mol
PPE : Eyeshields, Gloves, Respirator filter
Source : Synthetic
UV Visible Absorbance : ? max: 248 nm (Lit.)

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