(±)-Verapamil hydrochloride

Key Features and Details

(±)-Verapamil Hydrochloride

SYNONYMS: Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl) benzeneacetonitrile; a-isopropyl-a-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile
CAS: # 152-11-4
MOLECULAR FORMULA: C27H38N2O4·HCl
BEILSTEIN REGISTRY No.: 3647093
EC No: 205-800-5
MDL No: MFCD00055208
SKU 02195545-CF Categories , , Tag

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PRODUCT DESCRIPTION

(±)-Verapamil Hydrochloride

Application Notes

(±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Coronary vasodilator

SPECIFICATIONS
SKU: 02195545-CF
Base Catalog Number: 195545
Alternate Names: Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl) benzeneacetonitrile; a-isopropyl-a-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile
Beilstein Registration No : 3647093
Biochemical Physiological Actions : Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
CAS : # 152-11-4
EC No : 205-800-5
Extinction Coefficient : EmM = 16.1 (232 nm in ethanol); 6.1 (280 nm in ethanol)(Lit.)
Format : Powder
Hazard Statements : H301-H311-H331
MDL No : MFCD00055208
Molecular Formula : C27H38N2O4·HCl
pKa : 8.6 (Lit.)
PPE : Eyeshields, Faceshields, Gloves, Respirator cartridge
RTECS No : YV8320000
Safety Symbol : GHS06

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