2-Mercaptoethanol

Key Features and Details

2-Mercaptoethanol

SYNONYMS: 2-Hydroxyethylmercaptan ; ß-Mercaptoethanol; BME; Thioethylene glycol; 2-Hydroxy-1-ethanethiol; Monothioethyleneglycol ; 1-ethane-2-thiol; thioglycol ; 2-ME; b-ME; 2-thioethanol
CAS: # 60-24-2
MOLECULAR FORMULA: C2H6OS
MOLECULAR WEIGHT: 78.129 g/mol
BEILSTEIN REGISTRY No.: 773648
EC No: 200-464-6
MDL No: MFCD00004890
SKU 02194705-CF Categories , , Tag

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PRODUCT DESCRIPTION

2-Mercaptoethanol Application Notes 2-Mercaptoethanol is used to reduce disulfide linkages in solubilizing proteins for gel electrophoresis (typically used in SDS-PAGE sample buffer at 5% concentration). Also it reduces excess oxidative polymerization of catalysts. Cleaving intermolecular (between subunits) disulfide bonds allows the subunits of a protein to separate independently on SDS-PAGE. Cleaving intramolecular (within subunit) disulfide bonds allows the subunits to become completely denatured so that each peptide migrates according to its chain length with no influence due to secondary structure.In solution, 2-mercaptoethanol is readily oxidized in air to a disulfide, especially at alkaline pH. Because of this property, it is widely used to protect proteins, enzymes in particular, from becoming inactive. An excess of 2-mercaptoethanol (generally used at 0.01 M) will maintain the protein thiol groups in their reduced state. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Reducing agent
SPECIFICATIONS
SKU: 02194705-CF
Base Catalog Number: 194705
Alternate Names: 2-Hydroxyethylmercaptan ; ß-Mercaptoethanol; BME; Thioethylene glycol; 2-Hydroxy-1-ethanethiol; Monothioethyleneglycol ; 1-ethane-2-thiol; thioglycol ; 2-ME; b-ME; 2-thioethanol
Auto Ignition: 295°C
Beilstein Registration No : 773648
Boiling Point : 315 to 316° F at 742 mm Hg (decomposes) (NTP, 1992)
CAS : # 60-24-2
Density : 1.1143 at 68° F (NTP, 1992)
EC No : 200-464-6
Flash Point : 165° F (NFPA, 2010)
Format : Liquid
Formulation Details : The pure liquid (as supplied) is a 14.3 M liquid.
Grade : Cell Culture
Hazard Statements : H301 + H331-H310-H315-H317-H318-H373-H410
MDL No : MFCD00004890
Melting Point : -148° F (NTP, 1992)
Molecular Formula : C2H6OS
Molecular Weight : 78.129 g/mol
PPE : Faceshields, full-face respirator , Gloves, Goggles, multi-purpose combination respirator cartridge , respirator filter
Purity : =98%
Refractive Index : n20/D 1.500 (Lit.)
RTECS No : KL5600000
Safety Symbol : GHS05, GHS06, GHS08, GHS09
Solubility : greater than or equal to 100 mg/mL at 68° F (NTP, 1992)
Vapor Density : 2.69 (NTP, 1992) (Relative to Air)
Vapor Pressure : 1 mm Hg at 68° F (NTP, 1992)

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