Actinomycin D, cell culture reagent
Key Features and Details
Actinomycin D
SYNONYMS: Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen
CAS: #
50-76-0
MOLECULAR FORMULA: C62H86N12O16
MOLECULAR WEIGHT: 1255.438 g/mol
EC No: 200-063-6
MDL No: MFCD00005033
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PRODUCT DESCRIPTION
Actinomycin D
Application Notes
Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SPECIFICATIONS
SKU: 02194525-CF
Base Catalog Number: 194525
Alternate Names: Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen
Biochemical Physiological Actions
: Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
CAS
: #
50-76-0
EC No
: 200-063-6
Format
: Crystalline
Grade
: Cell Culture
Hazard Statements
: H300
MDL No
: MFCD00005033
Melting Point
: 467 to 469° F (decomposes) (NTP, 1992)
Molecular Formula
: C62H86N12O16
Molecular Weight
: 1255.438 g/mol
PPE
: Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge
Purity
: ~98%
Refractive Index
: 1.656(lit.)
RTECS No
: AU1575000
Safety Symbol
: GHS06
Solubility
: Soluble at 50° F (NTP, 1992)
Typical Working Concentration
: cell culture applications at 1µg/mL.
Vapor Pressure
: 0 mm Hg at 25 deg C (est)
