Alpha-2-macroglobulin, 1 mg
Key Features and Details
MOLECULAR WEIGHT: 725000
MDL No: MFCD00130472
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2-Macroglobulin is a tetrameric glycoprotein which acts as a broad-range irreversible protease inhibitor. It is found abundantly in plasma and interstitial fluids. The protease:alpha2-Macroglobulin balance plays an important role in mediating inflammation-associated tissue destruction. Serum levels of alpha2-macroglobulin and protease:alpha2-macroglobulin complexes are increased in patients with sepsis, emphysema, peridontitis, rheumatoid arthritis, and other inflammatory diseases. It is possible that the oxidant inactivation of alpha2-macroglobulin contributes to tissue destruction in inflammation. alpha2-Macroglobulin has been implicated as a genetic risk factor for late-onset Alzheimer's disease. Activated alpha2-macroglobulin enhances the clearance of soluble alpha/beta-amyloid via low-density lipoprotein receptor-related protein in cortical neurons but has no effect on secredted or full-length APP levels. Application Notes a2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Inhibitor
Base Catalog Number: 19134501
Alternate Names: a2-M;a2-Macroglobulin
Biochemical Physiological Actions : One mg of a2-macroglobulin will inhibit a minimum of 10 µg trypsin with an activity of 10,000 BAEE un/mg protein. a2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-a2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of a2-M and protease-a2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of a2-M may contribute to tissue destruction during inflammation.
MDL No : MFCD00130472
Molecular Weight : 725000
Purity : =95% (SDS-PAGE)
Solubility : Soluble in aqueous buffers. Sensitive to acidic pH; denatured below pH 4.0. Ammonia, methylamine, and hydroxylamine (above pH 7.0) cause irreversible conversion to the closed form. Do not use in the presence of DTT. 1 mg/13.8 uL = 100 uM solution.