Ampicillin (gamma irradiated), molecular biology grade, 20 mg
Key Features and Details
SYNONYMS: D[-]-a-Aminobenzylpenicillin; 6-[D(-)-a-Aminophenylacetamido]penicillanic acid; D-(-)-a-Aminobenzylpenicillin sodium salt; Aminobenzylpenicillin sodium salt
CAS: #
69-52-3
MOLECULAR FORMULA: C16H18N3NaO4S
MOLECULAR WEIGHT: 371.39
BEILSTEIN REGISTRY No.: 4119211
EC No: 200-708-1
MDL No: MFCD00064313
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PRODUCT DESCRIPTION
Ampicillin is a semi-synthetic derivative of penicillin, active as a broad-spectrum antibiotic.It is inactivated by beta-lactamases and for this reason a beta-lactamase inhibitor should be considered when using ampicillin. Against gram-positive bacteria, ampicillin has a similar mode of action as benzylpenicillin; against gram-negative bacteria, it has a similar mode of action as chloramphenicol and tetracyclines. In E. coli it inhibits cell wall synthesis.
Application Notes
Ampicillin sodium salt is used to select for ampicillin resistance in mutated and transformed cells. It is also described for the use of inhancing luminol chemiluminescence.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SPECIFICATIONS
SKU: 0219419920
Base Catalog Number: 19419920
Alternate Names: D[-]-a-Aminobenzylpenicillin; 6-[D(-)-a-Aminophenylacetamido]penicillanic acid; D-(-)-a-Aminobenzylpenicillin sodium salt; Aminobenzylpenicillin sodium salt
Beilstein Registration No
: 4119211
Biochemical Physiological Actions
: A ß-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli. Mode of resistance: Cleavage of ß-lactam ring of ampicillin by ß-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
CAS
: #
69-52-3
EC No
: 200-708-1
Grade
: Molecular Biology
Hazard Statements
: H317-H334
MDL No
: MFCD00064313
Melting Point
: 215 °C decomposes (Lit.)
Molecular Formula
: C16H18N3NaO4S
Molecular Weight
: 371.39
pH
: 8 - 10 (1% aq soln)
pKa
: At 25 °C ,pKa = 2.5 (-COOH),pKa = 7.3 (-NH2) (Lit.)
Potency
: =800 ug/mg
PPE
: Dust mask, Eyeshields, Faceshields, Gloves
RTECS No
: XH8400000
Safety Symbol
: GHS08
Solubility
: Soluble in water (50 mg/mL); soluble in 1 M Ammonium Hydroxide, dilute acids or bases; practically insoluble in alcohol, chloroform, ether and fixed oils.
Typical Working Concentration
: 100 mg/liter for both gram positive and gram negative bacteria
