Anisomycin
Key Features and Details
Anisomycin
SYNONYMS: 2-[p-Methoxybenzyl]-3,4- pyrrolidinediol 3-acetate; (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; Flagecidin
CAS: #
22862-76-6
MOLECULAR FORMULA: C14H19NO4
MOLECULAR WEIGHT: 265.309 g/mol
BEILSTEIN REGISTRY No.: 20705
EC No: 245-269-7
MDL No: MFCD00077650
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PRODUCT DESCRIPTION
Anisomycin
Application Notes
Anisomycin is an antiprotozoal agent. It inhibits protein synthesis. Activates a restricted subset of kinases currently only identified by p54 and MAP kinase. Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Inhibits protein synthesis | Activates a restricted subset of kinases | Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.
SPECIFICATIONS
SKU: 02159881-CF
Base Catalog Number: 159881
Alternate Names: 2-[p-Methoxybenzyl]-3,4- pyrrolidinediol 3-acetate; (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; Flagecidin
Beilstein Registration No
: 20705
Biochemical Physiological Actions
: Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
CAS
: #
22862-76-6
EC No
: 245-269-7
Format
: Powder
Hazard Statements
: H301
MDL No
: MFCD00077650
Molecular Formula
: C14H19NO4
Molecular Weight
: 265.309 g/mol
Optical Rotation: [a]D23 = -30 ° (methanol) (Lit.)
PPE
: Eyeshields, Faceshields, Gloves, respirator cartridges
Purity
: =97%
RTECS No
: BZ9800000
Safety Symbol
: GHS06
Source
: Streptomyces griseolus
