Aprotinin
Key Features and Details
Aprotinin
SYNONYMS: Pancreatic Basic Trypsin Inhibitor, polypeptide; Antagosan; Antikrein; Trasylol; Zymofren; Trypsin inhibitor (basic); Antilysin(e); BPTI; Bayer A 128; Kallikrein-trypsin inactivator; Fosten; Iniprol; Kunitz protease inhibitor; Onquinin; Repulson; RP-9921; Ryker 52G; Triazinin
CAS: #
9087-70-1
MOLECULAR FORMULA: C284H432N84O79S7
MOLECULAR WEIGHT: 6511.509 g/mol
EC No: 232-994-9
MDL No: MFCD00130541
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PRODUCT DESCRIPTION
Aprotinin
Application Notes
It is used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Serine protease inhibitor
SPECIFICATIONS
SKU: 02194559-CF
Base Catalog Number: 194559
Alternate Names: Pancreatic Basic Trypsin Inhibitor, polypeptide; Antagosan; Antikrein; Trasylol; Zymofren; Trypsin inhibitor (basic); Antilysin(e); BPTI; Bayer A 128; Kallikrein-trypsin inactivator; Fosten; Iniprol; Kunitz protease inhibitor; Onquinin; Repulson; RP-9921; Ryker 52G; Triazinin
Biochemical Physiological Actions
: Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or < 3.
CAS
: #
9087-70-1
EC No
: 232-994-9
Extinction Coefficient
: E1% (280 nm) = 8.3 (water)(Lit.)
Format
: Powder
Grade
: Cell Culture
Isoelectric Point
: 10.5(Lit.)
MDL No
: MFCD00130541
Melting Point
: >100 °C
Molecular Formula
: C284H432N84O79S7
Molecular Weight
: 6511.509 g/mol
PPE
: Eyeshields, Gloves, respirator filter
RTECS No
: YN5080000
Source
: Bovine Lung
Specific Activity
: ~4 inhibitor u/mg
Sterilization of Solutions
: Sterilization of solutions can be done by filtration through a 0.2 µm filter.
Typical Working Concentration
: Effective Concentration is Equimolar with protease (1-2 µg/mL).
Unit Definition
: One Kallikrein Inactivating Unit is the quantity of protease inhibitor that has the ability to inhibit 2 Kallikrein units by 50% under optimal conditions.
UV Visible Absorbance
: ? max (water) : 277 ± 5 nm
