Arachidonic acid

Key Features and Details

Arachidonic Acid

SYNONYMS: 5,8,11,14-Eicosatetraenoic Acid; (all-Z)-5,8,11,14-Eicosatetraenoic acid; cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid; Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid; Immunocytophyte
CAS: # 506-32-1
MOLECULAR WEIGHT: 304.474 g/mol
EC No: 208-033-4
MDL No: MFCD00004417
SKU 02150384-CF Categories , , , Tag

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Arachidonic Acid Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Activates protein kinase C
SKU: 02150384-CF
Base Catalog Number: 150384
Alternate Names: 5,8,11,14-Eicosatetraenoic Acid; (all-Z)-5,8,11,14-Eicosatetraenoic acid; cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid; Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid; Immunocytophyte
Beilstein Registration No : 1713889
Biochemical Physiological Actions : Arachidonic acid (AA) is an unsaturated ?6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) . Arachidonic acid plays a key role in cellular regulation and is controlled through multiple interconnected pathways. Changes in arachidonic acid levels correspond to the synthesis of eicosanoids resulting from receptor-stimulated lipid hydrolysis.It activates protein kinase C. Arachidonic acid serves as a precursor to numerous eicosanoids as well as other bioactive molecules.
Boiling Point : 170 °C at 1.50E-01 mm Hg
CAS : # 506-32-1
EC No : 208-033-4
Format : Liquid
Hazard Statements : May form explosive peroxides.
MDL No : MFCD00004417
Melting Point : -49.5 °C
Molecular Formula : C20H32O2
Molecular Weight : 304.474 g/mol
PPE : Eyeshields, Faceshields, Gloves, half-mask respirator, multi-purpose combination respirator cartridge
Purity : >98%
Refractive Index : n20/D 1.4872(Lit.)
RTECS No : CE6675000

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