Bafilomycin A1, 100 µg

Key Features and Details

Bafilomycin A1

CAS: # 88899-55-2
MOLECULAR WEIGHT: 622.84 g/mol
BEILSTEIN REGISTRY No.: 4730700
MDL No: MFCD06795130
SKU 0215955580 Categories , , Tag

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PRODUCT DESCRIPTION

Bafilomycin A1 Application Notes Bafilomycin A1 is active against gram-positive bacteria and fungi. It is a highly specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms, being effective at nanomolar concentrations in vitro. It inhibits neither F1, F10 nor E1, E2-ATPase. Bafilomycin A1 is useful in distinguishing among different types of ATPases. It is commonly employed to demonstrate the requirement of low endosomal pH for viral uncoating. It can inhibit growth of Capan-1 human pancreatic cancer cells and PC12 cells through apoptosis. Inhibition of V-ATPase by Bafilomycin A1 leads to increase in pH and decreased glycolysis, and thus reduced tumour cell mitosis and proliferation. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Active against gram-positive bacteria and fungi | ATPase inhibitor
SPECIFICATIONS
SKU: 0215955580
Base Catalog Number: 15955580
Beilstein Registration No : 4730700
Biochemical Physiological Actions : A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
CAS : # 88899-55-2
Format : Clear film
Hazard Statements : H315-H319-H335
MDL No : MFCD06795130
Molecular Weight : 622.84 g/mol
PPE : Dust mask, Eyeshields, Gloves
Purity : ~90%
Safety Symbol : GHS07
Source : Streptomyces griseus

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