Blasticidin S hydrochloride, phytopure
Key Features and Details
Number: 2079-00-7
SYNONYMS: BLA-S; Cytovirin; Blasticidine S hydrochloride; 4-[[3-Amino-5-[(aminoiminomethyl)-1-oxopentyl]amino]-1-(4-amino-2-oxo- 1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-b-D-erythro-hex-2-enopyranuronic acid
CAS: #
2079-00-7
MOLECULAR FORMULA: C
17
H
26
N
8
O
5
- HCl
MOLECULAR WEIGHT: 458.90
MDL No: MFCD02091640
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PRODUCT DESCRIPTION
Broad spectrum nucleoside antibiotic. Inhibits protein synthesis in prokaryotic and eukaryotic organisms. Suitable for selection of cells carrying plasmids conferring blasticidin resistance.
Application Notes
Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells. It is also used to study protein synthesis at the level of peptide bond formation.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antimicrobial
SPECIFICATIONS
SKU: 02150477-CF
Base Catalog Number: 150477
Alternate Names: BLA-S; Cytovirin; Blasticidine S hydrochloride; 4-[[3-Amino-5-[(aminoiminomethyl)-1-oxopentyl]amino]-1-(4-amino-2-oxo- 1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-b-D-erythro-hex-2-enopyranuronic acid
Biochemical Physiological Actions
: Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.
CAS
: #
2079-00-7
Hazard Statements
: H300
MDL No
: MFCD02091640
Molecular Formula
: C
17
H
26
N
8
O
5
- HCl
Molecular Weight
: 458.90
PPE
: Eyeshields, Faceshields, full-face particle respirator , Gloves, respirator filter, respirator cartridges
RTECS No
: EC4900000
Safety Symbol
: GHS06
Source
: Streptomyces griseochromogenes
Typical Working Concentration
: Typically used at 2 - 10 µg/mL for mammalian cell selection.
