C-Reactive protein, human
Key Features and Details
C-Reactive Protein, Human
SYNONYMS: CRP; C Reactive Protein from human plasma
CAS: # 9007-41-4
MDL No: MFCD00130690
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C-Reactive Protein, Human Application Notes C-Reactive Protein is used as an immunogen for antisera production and calibrator in the manufacturing of diagnostic kits for measuring serum CRP levels. CRP is found in elevated levels in a wide variety of acute inflammatory conditions. Activities of CRP include activation of the complement pathway, enhancement of phagocytosis, and inhibition of platelet aggregation. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Base Catalog Number: 152315
Alternate Names: CRP; C Reactive Protein from human plasma
Biochemical Physiological Actions : C reactive protein (CRP) is an acute phase protein. Serum levels in patients with atherosclerosis is predictive of increased risk of myocardial infarction (MI) and stroke. The cytokine IL-6 is thought to be the key mediator in hepatocyte secretion of acute phase proteins including CRP. CRP mediates innate immunity by binding to microbial polysaccharides and to ligands exposed on damaged cells. The binding activates the classical complement pathway (C1, C4, C2, C3 but not C5-9). Opsonization of the substrates leads to their uptake by phagocytic cells and limits the inflammatory response. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. In addition, CRP binds, through the Ca2+-dependent PC-binding site, to many other body components including phospholipids, lecithin, sphingomyelin, a variety of monophosphate esters, low density lipoprotein, fibronectin and to the basement membrane protein laminin. CRP binding to polycations has also been demonstrated, but this binding does not appear to occur through the PC-binding site on CRP.
CAS : # 9007-41-4
Format : Solution
MDL No : MFCD00130690
Preparation Method : Prepared from human pleural and ascites fluid and plasma.
Purity : =95%
Source : Human