Carboplatin, 25 mg
Key Features and Details
SYNONYMS: cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum; (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato (2-)-O,O']platinum
CAS: #
41575-94-4
MOLECULAR FORMULA: C6H12N2O4Pt
MOLECULAR WEIGHT: 371.25
EC No: 255-446-0
MDL No: MFCD00070464
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PRODUCT DESCRIPTION
Carboplatin is a platinum coordination compound and antineoplastic agent that is related to cisplatin.
Application Notes
A study of ?-glutamyltransferase overexpression in carboplatin-treated HeLa cells, with relation to cell defense mechanisms, has been reported. Mouse peritoneal macrophages treated with carboplatin have been shown to produce enhanced IL-1a and TNF-a levels in tissue culture supernatants. A 96 well assay study of the action of carboplatin on 10 human ovarian cancer cell lines has been described.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antineoplastic agent
SPECIFICATIONS
SKU: 0219887325
Base Catalog Number: 19887325
Alternate Names: cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum; (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato (2-)-O,O']platinum
Biochemical Physiological Actions
: Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.
CAS
: #
41575-94-4
EC No
: 255-446-0
Hazard Statements
: H302 + H312 + H332-H317-H334-H360
MDL No
: MFCD00070464
Molecular Formula
: C6H12N2O4Pt
Molecular Weight
: 371.25
PPE
: Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS No
: TP2300000
Safety Symbol
: GHS07, GHS08
Vapor Pressure
: 0.0187 Pa at melting point (Lit.)
