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Cephalexin monohydrate, USP grade, =95%
Key Features and Details
Cephalexin Monohydrate
SYNONYMS: 7-(d-a-Aminophenylacetamido)desacetoxycephalosporanic acid; Cefalexin monohydrate; [6R-[6a,7ß(R*)]]-7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid monohydrate; 7-(Da-aminophenylacetamido) desacetoxycephalosporanic acid monohydrate
CAS: #
23325-78-2
MOLECULAR FORMULA: C16H17N3O4S·H2O
MOLECULAR WEIGHT: 365.404 g/mol
BEILSTEIN REGISTRY No.: 965503
EC No: 239-773-6
MDL No: MFCD00167148
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PRODUCT DESCRIPTION
Cephalexin Monohydrate
Application Notes
Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis. Cephalexin and other antibiotics have been shown to inhibit p-aminohippurate uptake by the rat renal organic anion transporter 1, as expressed in Xenopus laevis oocytes. A study of CHO cells transfected with the vector for the H+-coupled peptide transporter PEPT1 has shown that cephalexin is a competitor for dipeptide transport. Cephalexin has been used to culture E. coli at 10 µg/mL for the expression of fusion proteins.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibacterial | Antibiotics
SPECIFICATIONS
SKU: 02150585-CF
Base Catalog Number: 150585
Alternate Names: 7-(d-a-Aminophenylacetamido)desacetoxycephalosporanic acid; Cefalexin monohydrate; [6R-[6a,7ß(R*)]]-7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid monohydrate; 7-(Da-aminophenylacetamido) desacetoxycephalosporanic acid monohydrate
Beilstein Registration No
: 965503
Biochemical Physiological Actions
: Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.
CAS
: #
23325-78-2
EC No
: 239-773-6
Extinction Coefficient
: 7.75(Lit.)
Format
: Powder
Grade
: USP
Hazard Statements
: H317-H334
MDL No
: MFCD00167148
Melting Point
: 326.8 °C
Molecular Formula
: C16H17N3O4S·H2O
Molecular Weight
: 365.404 g/mol
Optical Rotation: +149° to +158° (pH 4.4)
pKa
: 5.2, 7.3(Lit.)
Potency
: 950 - 1010 µg/mg (anhydrous basis)
PPE
: Dust mask , Eyeshields, Faceshields, Gloves
Purity
: =95%
RTECS No
: XI0350000
Safety Symbol
: GHS08
Solubility
: Water Solubility1.789 mg/mL as monohydrate salt (solubility in water is low at room temperature; 1 or 2 mg/mL may be dissolved readily, but higher concentrations are obtained with increasing difficulty)
UV Visible Absorbance
: 260 - 262 nm (water)
