Chloramphenicol, phytopure
Key Features and Details
Number: 56-75-7
SYNONYMS: D-(-)-threo-2,2-Dichloro-N-[ß-hydroxy-a-(hydroxymethyl)-ß-(4-nitrophenyl)ethyl]acetamide; D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[ß-hydroxy-a-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin; Anacetin; Chlomin; Embacetin; Mychel; veticol
CAS: #
56-75-7
MOLECULAR FORMULA: C
11
H
12
Cl
2
N
2
O
5
MOLECULAR WEIGHT: 323.20
BEILSTEIN REGISTRY No.: 2225532
EC No: 200-287-4
MDL No: MFCD00078159
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PRODUCT DESCRIPTION
A synthetic antibiotic first isolated from Streptomyces venezuelae. It is effective against gram-positive and gram-negative bacteria. It interferes with translation on the 50S ribosomal subunit at the peptidyl transferase step (elongation inhibition) and inhibits mitochondrial and chloroplast protein synthesis.
Application Notes
Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic (eye drops) and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
SPECIFICATIONS
SKU: 02190321-CF
Base Catalog Number: 190321
Alternate Names: D-(-)-threo-2,2-Dichloro-N-[ß-hydroxy-a-(hydroxymethyl)-ß-(4-nitrophenyl)ethyl]acetamide; D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[ß-hydroxy-a-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin; Anacetin; Chlomin; Embacetin; Mychel; veticol
Beilstein Registration No
: 2225532
Biochemical Physiological Actions
: Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Boiling Point
: Sublimes
CAS
: #
56-75-7
EC No
: 200-287-4
Extinction Coefficient
: (278 nm) = 298 (water) (Lit.)
Format
: Powder
Hazard Statements
: H350
MDL No
: MFCD00078159
Melting Point
: 171
Molecular Formula
: C
11
H
12
Cl
2
N
2
O
5
Molecular Weight
: 323.20
Optical Rotation: (c=5 ethanol)+18 ° ± 5 °
pH
: NEUTRAL TO LITMUS
PPE
: Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Purity
: >99%
RTECS No
: AB6825000
Safety Symbol
: GHS08
Solubility
: Water Solubility2500 mg/L (at 25 °C)
Typical Working Concentration
: 5 -20 µg/mL
Vapor Pressure
: 1.7X10-12 mm Hg at 25 deg C /Estimated/
