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Chloroquine diphosphate salt
Key Features and Details
Antibiotic
Antimalarial compound
SYNONYMS: Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
CAS: #
50-63-5
MOLECULAR FORMULA: C18H26N3Cl 2H3PO4
MOLECULAR WEIGHT: 515.865 g/mol
BEILSTEIN REGISTRY No.: 4223142
EC No: 200-055-2
MDL No: MFCD00069852
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PRODUCT DESCRIPTION
Chloroquine Diphosphate Salt
Application Notes
Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
SPECIFICATIONS
SKU: 02193919-CF
Base Catalog Number: 193919
Alternate Names: Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Beilstein Registration No
: 4223142
Biochemical Physiological Actions
: Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide).
CAS
: #
50-63-5
EC No
: 200-055-2
Hazard Statements
: H302
MDL No
: MFCD00069852
Melting Point
: 87 deg C
Molecular Formula
: C18H26N3Cl 2H3PO4
Molecular Weight
: 515.865 g/mol
pKa
: 4.0 - 5.0
Potency
: 8.4 and 10.8 (for chloroquine base at 20 °C)
PPE
: Dust mask type , Eyeshields, Gloves
RTECS No
: VB2450000
Solubility
: VERY SLIGHTLY SOL IN WATER; SOL IN DIL ACIDS, CHLOROFORM, ETHER
Source
: Soluble in water. Practically insoluble in alcohol; benzene; chloroform and ether.
Storage
: BIOCHEMICALS
Unit Definition
: Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 µM
Vapor Pressure
: 5.0X10-9 mm Hg at 25 deg C (est)
