Clozapine, 10 mg
Key Features and Details
SYNONYMS: HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
CAS: # 5786-21-0
MOLECULAR FORMULA: C18H19N4Cl
MOLECULAR WEIGHT: 326.83
EC No: 227-313-7
MDL No: MFCD00153785
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Clozapine is a dibenzodiazepine compound, structurally related to loxapine is used in cell signaling research. It is an a typical antipsychotic medication used in the treatment of schizophrenia. It is a dopamine D4 and D2 receptor antagonist which has high affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM). It is also a potent, selective muscarinic antagonist which exhibits the highest reported affinity for 5-HT1A and 5-HT1C sites. Application Notes Clozapine has dopamine receptor blocking activity, a-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Blocking of dopamine receptor
Base Catalog Number: 15976010
Alternate Names: HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
Biochemical Physiological Actions : A typical antipsychotic compound. Selective antagonist for D4- dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.
CAS : # 5786-21-0
EC No : 227-313-7
Extinction Coefficient : Ethanol: 27.4 (215 nm), 25.8 (230 nm), 16.8 (261 nm), 10.5 (297 nm) (Lit.)
Hazard Statements : H301-H341-H361
MDL No : MFCD00153785
Melting Point : 182-184 °C (lit.)
Molecular Formula : C18H19N4Cl
Molecular Weight : 326.83
Safety Symbol : GHS06, GHS08
Solubility : Soluble in 0.1M HC1 (25 mg/mL), ethanol (1 mg/mL) or DMSO (100 mM).