Key Features and Details


SYNONYMS: HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
CAS: # 5786-21-0
MOLECULAR WEIGHT: 326.828 g/mol
EC No: 227-313-7
MDL No: MFCD00153785
SKU 02159760-CF Categories , , Tag

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Clozapine Application Notes Clozapine has dopamine receptor blocking activity, a-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Blocking of dopamine receptor
SKU: 02159760-CF
Base Catalog Number: 159760
Alternate Names: HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
Biochemical Physiological Actions : A typical antipsychotic compound. Selective antagonist for D4- dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.
CAS : # 5786-21-0
EC No : 227-313-7
Extinction Coefficient : Ethanol: 27.4 (215 nm), 25.8 (230 nm), 16.8 (261 nm), 10.5 (297 nm) (Lit.)
Format : Powder
Hazard Statements : H301-H341-H361
MDL No : MFCD00153785
Melting Point : 183-184 °C
Molecular Formula : C18H19N4Cl
Molecular Weight : 326.828 g/mol
RTECS No : HP1750000
Safety Symbol : GHS06, GHS08
Solubility : Water Solubility11.8 mg/L
Vapor Pressure : 1.12X10-8 mm Hg at 25 deg C (est)

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