Colistin methanesulfonate, 25 mg
Key Features and Details
SYNONYMS: Sodium colistinemethanesulfonate; CLM; Colimycin M; Colimycin sodium methanesulfonate; Methanesulfonic acid derivative of Polymyxin E; Polymyxin E sodium methanesulfonate
CAS: #
8068-28-8
MOLECULAR FORMULA: C
58
H
105
N
16
Na
5
O
28
S
5
EC No: 232-516-9
MDL No: MFCD00130824
You need to register an account with us
to be able to place an order, Click to Register.
PRODUCT DESCRIPTION
Methanesulfonic acid derivative of polymyxin E.
Application Notes
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
SPECIFICATIONS
SKU: 0219415625
Base Catalog Number: 19415625
Alternate Names: Sodium colistinemethanesulfonate; CLM; Colimycin M; Colimycin sodium methanesulfonate; Methanesulfonic acid derivative of Polymyxin E; Polymyxin E sodium methanesulfonate
Biochemical Physiological Actions
: Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity. Antimicrobial spectrum: Gram-negative bacteria. Cyclopolypeptide antibiotic. Endotoxin-binding capacity Colistin's activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect .
CAS
: #
8068-28-8
EC No
: 232-516-9
MDL No
: MFCD00130824
Molecular Formula
: C
58
H
105
N
16
Na
5
O
28
S
5
PPE
: Eyeshields, Gloves, respirator filter
Solubility
: Soluble in water (200 mg plus 4 mL - clear to very slightly hazy colorless to light yellow solution).
Specific Activity
: =10,000 u/mg
