Demecolcine
Key Features and Details
Demecolcine, also known as colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic.
SYNONYMS: N-Deacetyl-N-methylcolchicine; 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one; N-Methyl-N-desacetylcolchicine; Colchamine; Santavy's substance F
CAS: #
477-30-5
MOLECULAR FORMULA: C21H25NO5
MOLECULAR WEIGHT: 371.4
BEILSTEIN REGISTRY No.: 2822892
EC No: 207-514-6
MDL No: MFCD00075459
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PRODUCT DESCRIPTION
Demecolcine, also known as colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic.
Application Notes
Demecolcine is a antineoplastic agent used to immobilize chromosomes by inactivating the spindle fiber mechanism during metaphase. Medically Demecolcine has been used to improve the results of cancer radiotherapy by synchronising tumour cells at metaphase, the radiosensitive stage of the cell cycle.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antineoplastic agent | Cancer research
SPECIFICATIONS
SKU: 02190195-CF
Base Catalog Number: 190195
Alternate Names: N-Deacetyl-N-methylcolchicine; 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one; N-Methyl-N-desacetylcolchicine; Colchamine; Santavy's substance F
Beilstein Registration No
: 2822892
Biochemical Physiological Actions
: Demecolcine depolymerizes microtubules; blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
CAS
: #
477-30-5
EC No
: 207-514-6
Hazard Statements
: H300
MDL No
: MFCD00075459
Melting Point
: 186 °C (Lit.)
Molecular Formula
: C21H25NO5
Molecular Weight
: 371.4
PPE
: Eyeshields, Faceshields, Gloves, respirator cartridges
Purity
: >98%
RTECS No
: GH0800000
Safety Symbol
: GHS06
Solubility
: Soluble in acidified water, alcohol, ether, chloroform (10 mg/mL - clear, faint yellow solution) and benzene.
Typical Working Concentration
: Used in cell culture medium at a final concentration of 0.4 ug/mL.
