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Doxorubicin hydrochloride,=95%
Key Features and Details
Doxorubicin Hydrochloride
SYNONYMS: Adriamycin; 14-Hydroxydaunomycin; HCl; DOX; Hydroxydaunorubicin hydrochloride; 14-Hydroxydaunomycin hydrochloride; 10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl) hydrochloride; Doxorubicin
CAS: #
25316-40-9
MOLECULAR FORMULA: C27H29NO11·HCl
MOLECULAR WEIGHT: 579.983 g/mol
BEILSTEIN REGISTRY No.: 4229251
EC No: 246-818-3
MDL No: MFCD00077757
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PRODUCT DESCRIPTION
Doxorubicin Hydrochloride
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Chemotherapeutic agent
SPECIFICATIONS
SKU: 02159101-CF
Base Catalog Number: 159101
Alternate Names: Adriamycin; 14-Hydroxydaunomycin; HCl; DOX; Hydroxydaunorubicin hydrochloride; 14-Hydroxydaunomycin hydrochloride; 10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl) hydrochloride; Doxorubicin
Beilstein Registration No
: 4229251
Biochemical Physiological Actions
: Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis. Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
CAS
: #
25316-40-9
EC No
: 246-818-3
Format
: Powder
Hazard Statements
: H302-H350
MDL No
: MFCD00077757
Melting Point
: 399 to 401° F (Decomposes) (NTP, 1992)
Molecular Formula
: C27H29NO11·HCl
Molecular Weight
: 579.983 g/mol
PPE
: Eyeshields, Full-face respirator, Gloves, Multi-purpose combination respirator cartridge, Respirator filter
Purity
: =95%
RTECS No
: QI9295900
Safety Symbol
: GHS07, GHS08
Solubility
: Soluble (NTP, 1992)
Vapor Pressure
: 2.5X10-23 at 25 deg C (est)
