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Elastatinal, =50%, 1 mg
Key Features and Details
SYNONYMS: (2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide; N-(Na-Carbonyl-Cpd-Gln-Ala-al)-Leu where Cpd = capreomycidine = (S,S)-a-[2-Iminohexahydro-4-pyrimidylglycine]
CAS: # 51798-45-9
MOLECULAR FORMULA: C21H36N8O7
MOLECULAR WEIGHT: 512.57
BEILSTEIN REGISTRY No.: 873543
EC No: 257-426-7
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PRODUCT DESCRIPTION
SPECIFICATIONS
SKU: 0215284701
Base Catalog Number: 15284701
Alternate Names: (2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide; N-(Na-Carbonyl-Cpd-Gln-Ala-al)-Leu where Cpd = capreomycidine = (S,S)-a-[2-Iminohexahydro-4-pyrimidylglycine]
Beilstein Registration No
: 873543
Biochemical Physiological Actions
: Potent, irreversible elastase inhibitor (Ki = 240 nM). Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes. Elastatinal is a strong competitive inhibitor of elastase which is found in some species of Streptomyces, showing 50% inhibition at 0.29 ug/mL, while greater than 250 ug/mL is required for other proteases.
CAS
: # 51798-45-9
EC No
: 257-426-7
Extinction Coefficient
: E1% = 1.5 (0.1 N HCl), 2.5 (0.1 M phosphate, pH 7.0)(Lit.)
Molecular Formula
: C21H36N8O7
Molecular Weight
: 512.57
pKa
: 3.7 and >10.5 (Lit.)
PPE
: Eyeshields, Gloves, respirator filter
Purity
: =50%
RTECS No
: LZ9600000
Solubility
: Soluble in water (20 mg/mL - clear solution), DMSO, or methanol. Also soluble in pyridine, dimethyl sulfoxide, and slightly soluble in ethanol.
Typical Working Concentration
: Effective concentration is typically 0.5 to 2 ug/mL.
UV Visible Absorbance
: ?max: 275 nm, 298 nm (Lit.)
