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Fibronectin
Key Features and Details
Fibronectin
SYNONYMS: CIG; Cold insoluble globulin
CAS: #
86088-83-7
EC No: 289-149-2
MDL No: MFCD00131062
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PRODUCT DESCRIPTION
Fibronectin
Application Notes
Fibronectin has been shown to stimulate the proliferation of rat osteoblasts in vitro; to induce odontoblast polarization and to regulate the differentiation of human dental pulp cells into odontoblasts. It has wide applications in cellular research into proliferation, differentiation, development and morphology. Precoating of glass, plastic and micro-carrier beads aids cell attachment, particularly those cell which are deficient in cell surface fibronectin. It has been reported that proteolytic digests of fibronectin are mitogenic for CH23 fibroblasts.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Glycoproteins
SPECIFICATIONS
SKU: 02150025-CF
Base Catalog Number: 150025
Alternate Names: CIG; Cold insoluble globulin
Biochemical Physiological Actions
: Domains of fibronectin bind with collagen, fibrin, heparin, and specific cell membrane receptors. The most notable domain, Arg-Gly-Asp can be recognized by integrins and mediates cell adhesion. Fibronectin is also widely involved in interactions such as the attachment and migration of many cell types, cytoskeletal assembly, tyrosine phosphorylation, and metastasis.
CAS
: #
86088-83-7
EC No
: 289-149-2
Extinction Coefficient
: E1%= 12.9 (280 nm in 8 M urea-0.2 M NaOH)(Lit.)
Format
: Lyophilized powder
Isoelectric Point
: 5.5 - 6.3 (Lit.)
MDL No
: MFCD00131062
PPE
: Eyeshields, Gloves, Respirator filter
Purity
: =90%
Source
: Bovine Plasma
Sterility
: Sterile Filtered
Typical Working Concentration
: 5-25 µg/mL (average is 10 µg/mL). Enrofloxacin is typically used for approximately 12 to 20 days in cell culture media with the media being changed every 3 to 4 days. Oral adminstration is typically given at 10 mg/kg; IV administration is typically given at 5 mg/kg.
