Furazolidone
Key Features and Details
Furazolidone
SYNONYMS: 3-[[(5-Nitro-2-furanyl)methylene]-amino]-2-oxazolidinone; 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone; Furovag; Furoxane; Medaron; Topazone
CAS: #
67-45-8
MOLECULAR FORMULA: C8H7N3O5
MOLECULAR WEIGHT: 225.16 g/mol
BEILSTEIN REGISTRY No.: 8317414
EC No: 200-653-3
MDL No: MFCD00010550
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PRODUCT DESCRIPTION
Furazolidone
Application Notes
Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. It also used as a DNA interstrand cross-linking agent.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibacterial
SPECIFICATIONS
SKU: 02193465-CF
Base Catalog Number: 193465
Alternate Names: 3-[[(5-Nitro-2-furanyl)methylene]-amino]-2-oxazolidinone; 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone; Furovag; Furoxane; Medaron; Topazone
Beilstein Registration No
: 8317414
Biochemical Physiological Actions
: Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor. It increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes.
CAS
: #
67-45-8
EC No
: 200-653-3
Format
: Powder
Hazard Statements
: H361
MDL No
: MFCD00010550
Melting Point
: 254-256
Molecular Formula
: C8H7N3O5
Molecular Weight
: 225.16 g/mol
PPE
: Eyeshields, full-face particle respirator, Gloves, respirator filter,respirator cartridges
RTECS No
: RQ3675000
Safety Symbol
: GHS08
Solubility
: Water Solubility40 mg/L (at 25 °C)
