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Indomethacin, =98%
Key Features and Details
Indomethacin
SYNONYMS: Indometacin; 1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid; 1-(4-Chlorobenzoyl)-5- methoxy-2-methyl-1H-indole-3-acetic acid; 1-(p-Chlorobenzoyl)-5- methoxy-2-methyl-3- indolylacetic acid
CAS: #
53-86-1
MOLECULAR FORMULA: C19H16ClNO4
MOLECULAR WEIGHT: 357.79 g/mol
BEILSTEIN REGISTRY No.: 497341
EC No: 200-186-5
MDL No: MFCD00057095
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PRODUCT DESCRIPTION
Indomethacin
Application Notes
Inhibitor of cyclooxygenase (prostaglandin H synthase 1 and 2). An anti-inflammatory (by blocking prostaglandin biosynthesis by inhibiting cyclooxygenase), antipyretic and analgesic agent. May help prevent the stimulation of tumor cell growth and the suppression of immune surveillance caused by cyclooxygenase's ability to convert arachidonic acid to pro-inflammatory substances such as prostaglandins. Indomethacin is metabolized by the liver and the metabolites excreted in the urine.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotics | Antitumor Agent
SPECIFICATIONS
SKU: 02190217-CF
Base Catalog Number: 190217
Alternate Names: Indometacin; 1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid; 1-(4-Chlorobenzoyl)-5- methoxy-2-methyl-1H-indole-3-acetic acid; 1-(p-Chlorobenzoyl)-5- methoxy-2-methyl-3- indolylacetic acid
Beilstein Registration No
: 497341
Biochemical Physiological Actions
: Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
CAS
: #
53-86-1
EC No
: 200-186-5
Extinction Coefficient
: EmM (230 nm) = 20.8 (in ethanol), EmM (260 nm) = 16.2 (in ethanol), EmM (319 nm) = 6.29 (in ethanol),(Lit.)
Format
: Powder
Hazard Statements
: H300
MDL No
: MFCD00057095
Melting Point
: 311 or 323.6° F (NTP, 1992)
Molecular Formula
: C19H16ClNO4
Molecular Weight
: 357.79 g/mol
pKa
: 4.5(Lit.)
PPE
: Eyeshields, Faceshields, full-face particle respirator, Gloves, Respirator cartridge,Respirator filter
Purity
: =98%
RTECS No
: NL3500000
Safety Symbol
: GHS06
Solubility
: Water Solubility0.937 mg/L (at 25 °C)
Vapor Pressure
: 9.89X10-11 mm Hg at 25 deg C (est)
