Ketoconazole, =98%
Key Features and Details
Ketoconazole
SYNONYMS: cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1M-idazol-1-ylmethyl)-1,3-dioxolan-4-yl) methoxy) phenyl)-piperazine; Fungarest; Fungoral; Ketoconazol; Ketoderm; Ketoisdin; KW-1414; Nizoral; R 41400; (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
CAS: #
65277-42-1
MOLECULAR FORMULA: C26H28N4O4Cl2
MOLECULAR WEIGHT: 531.434 g/mol
EC No: 265-667-4
MDL No: MFCD00058579
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PRODUCT DESCRIPTION
Ketoconazole
Application Notes
Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is a CYP3A4 inhibitor. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotics | Antifungal | Enzyme
SPECIFICATIONS
SKU: 02159158-CF
Base Catalog Number: 159158
Alternate Names: cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1M-idazol-1-ylmethyl)-1,3-dioxolan-4-yl) methoxy) phenyl)-piperazine; Fungarest; Fungoral; Ketoconazol; Ketoderm; Ketoisdin; KW-1414; Nizoral; R 41400; (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
Biochemical Physiological Actions
: Ketoconazole as an Antifungal agent, interacts with 14-a demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .
CAS
: #
65277-42-1
EC No
: 265-667-4
Format
: Powder
Hazard Statements
: H301-H360F-H373-H410
MDL No
: MFCD00058579
Melting Point
: 146
Molecular Formula
: C26H28N4O4Cl2
Molecular Weight
: 531.434 g/mol
PPE
: Eyeshields, Faceshields, Respirator cartridges
Purity
: =98%
RTECS No
: TK7912300
Safety Symbol
: GHS06, GHS08, GHS09
Solubility
:
Water Solubility
0.0866 mg/LVapor Pressure
: 6.41X10-14 mm Hg at 25 deg C (est)
