No products in the cart.
L-Histidine, monohydrochloride, monohydrate
Key Features and Details
L-Histidine Monohydrochloride Monohydrate
SYNONYMS: L-a-Amino-ß-(4-imidazolyl)propionic acid monohydrochloride; (S)-a-amino-1H-imidazole-4-propanoic acid hydrochloride; glyoxaline-5-alanine hydrochloride;His;H
CAS: #
5934-29-2
MOLECULAR FORMULA: C6H9N3O2 HCl H2O
MOLECULAR WEIGHT: 209.63 g/mol
BEILSTEIN REGISTRY No.: 4168261
MDL No: MFCD00151027
You need to register an account with us
to be able to place an order, Click to Register.
PRODUCT DESCRIPTION
L-Histidine Monohydrochloride Monohydrate
Application Notes
L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilized as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. An in vivo study has used L-histidine to diminish the net secretory response of the small intestine of of cholera toxin-challenged mice.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
SPECIFICATIONS
SKU: 02101957-CF
Base Catalog Number: 101957
Alternate Names: L-a-Amino-ß-(4-imidazolyl)propionic acid monohydrochloride; (S)-a-amino-1H-imidazole-4-propanoic acid hydrochloride; glyoxaline-5-alanine hydrochloride;His;H
Beilstein Registration No
: 4168261
Biochemical Physiological Actions
: Because the pKa of the imidazole group is close to physiological pH, the imidazole moiety can be either uncharged or positively charged, depending on the local environment. This property makes histidine residues of exceptional interest in the active sites of many proteins, such as hemoglobin and myoglobin, where the imidazole ring can readily alternate between the charged (imidazolium) and uncharged (imidazole) states to participate in bond formation and breakage. Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. In turn, histidine is degraded to glutamate by histidase, urocanase, and imidazolonepropionase via the formation of urocanate, 4-imidazolone 5-propionate, and N-formiminoglutamate.
CAS
: #
5934-29-2
Format
: Powder
Isoelectric Point
: 7.641(Lit.)
MDL No
: MFCD00151027
Molecular Formula
: C6H9N3O2 HCl H2O
Molecular Weight
: 209.63 g/mol
Optical Rotation: +9.5° ± 1° (c = 1, 6NHCl)
pKa
: 1.80 (COOH), 9.33 (NH2), 6.04 (imidazole group)(Lit.)
PPE
: Eyeshields, Gloves, respirator filter
RTECS No
: MS3119000
