Leupeptin hemisulfate
Key Features and Details
Leupeptin Hemisulfate
SYNONYMS: Acetyl-Leu-Leu-Arg-al
CAS: #
103476-89-7
MOLECULAR FORMULA: C20H38N6O4 • 1/2H2SO4
MOLECULAR WEIGHT: 951.196 g/mol
MDL No: MFCD00037012
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PRODUCT DESCRIPTION
Leupeptin Hemisulfate
Application Notes
Leupeptin is a Inhibitor for trypsin, plasmin, papain, and cathepsin B.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Inhibitor
SPECIFICATIONS
SKU: 02151553-CF
Base Catalog Number: 151553
Alternate Names: Acetyl-Leu-Leu-Arg-al
Biochemical Physiological Actions
: Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or a-chymotrypsin. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
CAS
: #
103476-89-7
MDL No
: MFCD00037012
Molecular Formula
: C20H38N6O4 • 1/2H2SO4
Molecular Weight
: 951.196 g/mol
PPE
: Eyeshields, Gloves, respirator filter
Typical Working Concentration
: Effective concentration 10-100 µM.
