Naloxone hydrochloride
Key Features and Details
Naloxone Hydrochloride
SYNONYMS: Narcan; EN-1530; (5a)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride; 17-allyl-4,5a- epoxy-3,14-dihydroxymorphinan-6-one hydrochloride; (-)-N-allyl-14- hydroxynordihydromorphinone; N-allylnoroxymorphone;
CAS: #
357-08-4
MOLECULAR FORMULA: C19H21NO4 • HCl
BEILSTEIN REGISTRY No.: 6260807
EC No: 206-611-0
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PRODUCT DESCRIPTION
Naloxone Hydrochloride
Application Notes
The role of naloxone (1 µM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100 µM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors. Naloxone has also been utilized to modulate the NMDA receptor activation capability of the µ-opioid receptor agonist DAMGO.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Opiate antagonist
SPECIFICATIONS
SKU: 02190245-CF
Base Catalog Number: 190245
Alternate Names: Narcan; EN-1530; (5a)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride; 17-allyl-4,5a- epoxy-3,14-dihydroxymorphinan-6-one hydrochloride; (-)-N-allyl-14- hydroxynordihydromorphinone; N-allylnoroxymorphone;
Beilstein Registration No
: 6260807
Biochemical Physiological Actions
: Naloxone has an extremely high affinity for µ-opioid receptors in the central nervous system. Naloxone is a µ-opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Naloxone also has an antagonist action, though with a lower affinity, at ?- and d-opioid receptors.
CAS
: #
357-08-4
EC No
: 206-611-0
Format
: Crystalline powder
Hazard Statements
: H315-H319-H335
Molecular Formula
: C19H21NO4 • HCl
PPE
: Dust mask, Eyeshields, Gloves
RTECS No
: QD2275000
Safety Symbol
: GHS07
