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Niclosamide
Key Features and Details
Niclosamide
SYNONYMS: 2´,5-Dichloro-4-nitrosalicylanilide
CAS: #
50-65-7
MOLECULAR FORMULA: C13H8Cl2N2O4
MOLECULAR WEIGHT: 327.117 g/mol
BEILSTEIN REGISTRY No.: 2820605
EC No: 200-056-8
MDL No: MFCD00057597
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PRODUCT DESCRIPTION
Niclosamide
Application Notes
Niclosamide is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-?B in AML cells and ito induce apoptosis.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Inhibit the transcription and DNA binding of NF-?B in AML cells
SPECIFICATIONS
SKU: 02155827-CF
Base Catalog Number: 155827
Alternate Names: 2´,5-Dichloro-4-nitrosalicylanilide
Beilstein Registration No
: 2820605
Biochemical Physiological Actions
: Niclosamide uncouples oxidative phosphorylation in the tapeworm. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It inhibits the NF-?B pathway in acute myelogenous leukemia (AML) cells. Niclosamide inhibits the transcription and DNA binding of NF-?B. It blocks tumor necrosis factor-induced I?Ba phosphorylation, translocation of p65, and expression of NF-?B regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells.
CAS
: #
50-65-7
EC No
: 200-056-8
Format
: Powder
Hazard Statements
: H400
MDL No
: MFCD00057597
Melting Point
: 230 °C
Molecular Formula
: C13H8Cl2N2O4
Molecular Weight
: 327.117 g/mol
PPE
: Eyeshields, Gloves, Respirator filter
Purity
: =98%
RTECS No
: VN8400000
Safety Symbol
: GHS09
Solubility
: Water Solubility1.6 mg/L (at 20 °C)
Vapor Pressure
: <9.87X10-9 mm Hg at 20 deg C
