Nodularin, 500 UG
Key Features and Details
SYNONYMS: 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
CAS: #
118399-22-7
MOLECULAR FORMULA: C
41
H
60
N
8
O
10
MOLECULAR WEIGHT: 825
MDL No: MFCD16659855
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PRODUCT DESCRIPTION
Potent in the inhibition of protein phosphatases 1 and 2A (PP1 and PP2A)
Similar to Microcystin-LR, but with increased water solubility
Application Notes
Useful for affinity purification of PP2A
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
SPECIFICATIONS
SKU: 0215838090
Base Catalog Number: 15838090
Alternate Names: 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
Biochemical Physiological Actions
: Non-cell permeable protein phosphatase inhibitor. Hepatotoxic, cyclic peptide related to microcystin LR with a similar activity profile. It does not induce any effects on mouse skin or human fibroblasts.Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.
CAS
: #
118399-22-7
Hazard Statements
: H300 +H310 + H330-H315-H317-H319-H335
MDL No
: MFCD16659855
Molecular Formula
: C
41
H
60
N
8
O
10
Molecular Weight
: 825
RTECS No
: GU2294250
Safety Symbol
: GHS06
Solubility
: Soluble in DMSO and methanol (2 mg/mL), water (15% methanol v/v), ethanol.
