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Patulin, 2 mg
Key Features and Details
SYNONYMS: 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one; claviformin; clavitin; expansin; clavacin; penicidin; mycoin C; mycoin; leucopin; tercinin
CAS: #
149-29-1
MOLECULAR FORMULA: C7H6O4
MOLECULAR WEIGHT: 154.1
BEILSTEIN REGISTRY No.: 149675
EC No: 205-735-2
MDL No: MFCD00005858
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PRODUCT DESCRIPTION
Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It blocks the farnesylation of proteins in a cell free assay. It inhibits the incorporation of 3H-mevalonate into proteins found in complete cells.
Application Notes
Patulin is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking. It is used to study patulin contamination of bottled wine, DNA-damaging activity of patulin in Escherichia coli., and molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in patulin biosynthesis.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Inhibitor of potassium uptake | Study of patulin contamination of bottled wine
SPECIFICATIONS
SKU: 0215998902
Base Catalog Number: 15998902
Alternate Names: 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one; claviformin; clavitin; expansin; clavacin; penicidin; mycoin C; mycoin; leucopin; tercinin
Beilstein Registration No
: 149675
Biochemical Physiological Actions
: Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking. CYP619 cytochrome P450s are involved in biosynthesis of patulin in Aspergillus clavatus.
CAS
: #
149-29-1
EC No
: 205-735-2
Extinction Coefficient
: EM(276 nm) = 14,600 (methanol)(Lit.)
Hazard Statements
: H300-H315
MDL No
: MFCD00005858
Melting Point
: 107 - 110 °C(Lit.)
Molecular Formula
: C7H6O4
Molecular Weight
: 154.1
PPE
: Eyeshields, Gloves
RTECS No
: LV2625000
Safety Symbol
: GHS06
Solubility
: Soluble in ethyl acetate (5 mg in 0.1 mL), in dichloromethane (10 mg/mL), in water, DMSO(10 mg/mL) and ethanol (25 mg/ mL). Sparingly soluble in ethyl ether or benzene.
