Pepstatin A

Key Features and Details

Reversible inhibitor of acid proteases
Does not inhibit thiol proteases, neutral proteases or serine proteases
Forms a 1:1 complex with acid proteases (carboxyl proteases)

SYNONYMS: Isovaleryl-L-valyl-L-valyl-[(3S, 4S)-4-amino-3-hydroxy-6- methylheptanoyl]-L- alanyl [3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid]; [1S-[1R*,2R*,4[R*[R*(R*)]]]]-N- (3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3- methylbutyl] amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide; N-isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-g-aminoheptanoyl-L- alanyl-3-hydroxy-6-methyl-g-aminoheptanoic acid
CAS: # 26305-03-3
MOLECULAR FORMULA: C34H63N5O9
BEILSTEIN REGISTRY No.: 2201362
EC No: 247-600-0
MDL No: MFCD00060740
SKU 02195368-CF Categories , , Tag

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PRODUCT DESCRIPTION

Pepstatin A Application Notes Pepstatin A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Inhibition | Protein Inhibitor
SPECIFICATIONS
SKU: 02195368-CF
Base Catalog Number: 195368
Alternate Names: Isovaleryl-L-valyl-L-valyl-[(3S, 4S)-4-amino-3-hydroxy-6- methylheptanoyl]-L- alanyl [3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid]; [1S-[1R*,2R*,4[R*[R*(R*)]]]]-N- (3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3- methylbutyl] amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide; N-isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-g-aminoheptanoyl-L- alanyl-3-hydroxy-6-methyl-g-aminoheptanoic acid
Beilstein Registration No : 2201362
Biochemical Physiological Actions : Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized ?-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.
CAS : # 26305-03-3
EC No : 247-600-0
Hazard Statements : H317
MDL No : MFCD00060740
Molecular Formula : C34H63N5O9
PPE : Eyeshields, Gloves,respirator filter
RTECS No : SC6155000
Typical Working Concentration : Effective concentration is approximately 1 uM (0.5 to 1.0 ug/mL).

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