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Phorbol 12-myristate 13-acetate, molecular biology reagent, ~99%
Key Features and Details
Phorbol 12-Myristate 13-Acetate
SYNONYMS: Phorbol Myristate Acetate; Phorbol Acetate Myristate; PMA; TPA; 12-O-Tetradecanoyl-phorbol 13-acetate; 4ß,9a,12ß,13a,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
CAS: #
16561-29-8
MOLECULAR FORMULA: C36H56O8
MOLECULAR WEIGHT: 616.836 g/mol
BEILSTEIN REGISTRY No.: 2407201
MDL No: MFCD00036736
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PRODUCT DESCRIPTION
Phorbol 12-Myristate 13-Acetate
Application Notes
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Potent tumor promoter
SPECIFICATIONS
SKU: 02194804-CF
Base Catalog Number: 194804
Alternate Names: Phorbol Myristate Acetate; Phorbol Acetate Myristate; PMA; TPA; 12-O-Tetradecanoyl-phorbol 13-acetate; 4ß,9a,12ß,13a,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
Beilstein Registration No
: 2407201
Biochemical Physiological Actions
: Potent tumor promoter; activates protein kinase C in vivo and in vitro.
CAS
: #
16561-29-8
Grade
: Molecular Biology
Hazard Statements
: H315
MDL No
: MFCD00036736
Melting Point
: 162° F (NTP, 1992)
Molecular Formula
: C36H56O8
Molecular Weight
: 616.836 g/mol
PPE
: Dust mask, Eyeshields, Gloves
Purity
: 99%
RTECS No
: QH4377000
Safety Symbol
: GHS07
Solubility
: Practically insoluble (NTP, 1992)
Vapor Pressure
: 1.8X10-17 mm Hg at 25 deg C (est)
