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PRODUCT DESCRIPTION
Pimaricin
Application Notes
Pimaricin is an amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. It is used to study pimaricin biosynthesis1 and as a fungicide in agar media.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
Biochemical Physiological Actions
: An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane.
CAS
: #
7681-93-8
EC No
: 231-683-5
Format
: Suspension
MDL No
: MFCD00135085
Melting Point
: 290 dec °C
Molecular Formula
: C33H47NO13
Molecular Weight
: 665.733 g/mol
pH
: 5,5-7,5 (1 % w/v solution in previously neutralised mixture of 20 parts dimethylformamide and 80 parts of water)