Polymyxin B sulfate, Cell Culture Reagent
Key Features and Details
Polymyxin B Sulfate
SYNONYMS: Aerosporin
CAS: #
1405-20-5
MOLECULAR FORMULA: C55H96N16O13·2H2SO4
MOLECULAR WEIGHT: 1301.571 g/mol
EC No: 215-774-7
MDL No: MFCD00131991
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PRODUCT DESCRIPTION
Polymyxin B Sulfate
Application Notes
It is used as a lipid A binding agent that induces pore formation in cell membranes and as immobilized (substrate bound) agent for removal of endotoxins. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SPECIFICATIONS
SKU: 02194538-CF
Base Catalog Number: 194538
Alternate Names: Aerosporin
Biochemical Physiological Actions
: Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Gram-negative bacteria.
CAS
: #
1405-20-5
EC No
: 215-774-7
Format
: Powder
Grade
: Cell Culture
Hazard Statements
: H302
MDL No
: MFCD00131991
Molecular Formula
: C55H96N16O13·2H2SO4
Molecular Weight
: 1301.571 g/mol
Potency
: >6,000 u/mg
PPE
: Dust mask , Eyeshields, Gloves
Safety Symbol
: GHS07
Solubility
: Water Solubility25 mg/mL
Typical Working Concentration
: 50 mg/L
