Polymyxin B sulfate

Key Features and Details

Polymyxin B Sulfate

SYNONYMS: Aerosporin
CAS: # 1405-20-5
MOLECULAR WEIGHT: 1301.571 g/mol
EC No: 215-774-7
MDL No: MFCD00131991
SKU 02100565-CF Categories , , Tag

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Polymyxin B Sulfate Application Notes Polymyxin B sulfate is a mixture of Polymyxin B1 and B2 sulfate. It is used clinically to treat infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. It is used to study multidrug-resistant pathogens. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Cell culture
SKU: 02100565-CF
Base Catalog Number: 100565
Alternate Names: Aerosporin
Biochemical Physiological Actions : Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
CAS : # 1405-20-5
EC No : 215-774-7
Format : Powder
Hazard Statements : H302
MDL No : MFCD00131991
Molecular Formula : C55H96N16O13·2H2SO4
Molecular Weight : 1301.571 g/mol
pKa : 43227
PPE : Dust mask, Eyeshields, Gloves
RTECS No : TR1150000
Solubility : Water Solubility25 mg/mL
Source : Soluble in water; 1 mM HCl
Unit Definition : Effective concentration is typically 50 mg/L.

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