Sodium valproate
Key Features and Details
Sodium Valproate
SYNONYMS: 2-Propyl pentanoic acid; Valproic acid sodium salt; Sodium 2-propylpentanoate
CAS: #
1069-66-5
MOLECULAR FORMULA: C8H15NaO2
MOLECULAR WEIGHT: 166.196 g/mol
EC No: 213-961-8
MDL No: MFCD00078604
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PRODUCT DESCRIPTION
Sodium Valproate
Application Notes
Sodium Valproate is reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3a and GSK-3ß. Valproic Acid has been reported to be a potent inhibitor of HDAC (histone deacetylase) in vitro (IC50 = 400 µM for HDAC1), thereby relieving HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase. This compound is also an inhibitor of the CYP2C9 enzyme.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Anticonvulsant
SPECIFICATIONS
SKU: 02152064-CF
Base Catalog Number: 152064
Alternate Names: 2-Propyl pentanoic acid; Valproic acid sodium salt; Sodium 2-propylpentanoate
Biochemical Physiological Actions
: Anti-convulsant that also has efficacy as a mood stabilizer in bipolar disorder.
Boiling Point
: 219.5 deg C
CAS
: #
1069-66-5
Density
: 0.904 g/cu cm at 25 deg C
EC No
: 213-961-8
Format
: Crystalline powder
Hazard Statements
: H302
MDL No
: MFCD00078604
Molecular Formula
: C8H15NaO2
Molecular Weight
: 166.196 g/mol
PPE
: Dust mask , Eyeshields, Gloves
RTECS No
: YV7876000
Safety Symbol
: GHS07
Solubility
: In water, 2.0X10+3 mg/L at 20 deg C
Vapor Pressure
: 8.47X10-2 mm Hg at 25 deg C (est)
