Spermine
Key Features and Details
Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine through the addition of aminopropyl group to spermidine by spermine synthase. It is found as a polycation at physiological pH.
SYNONYMS: Diaminopropyltetramethylenediamine; Gerontine; Musculamine; Neuridine; N,N-bis(aminopropyl)-1,4-butanediamine; 4,9-Diaza-1,12-dodecanediamine
CAS: #
71-44-3
MOLECULAR FORMULA: C10H26N4
MOLECULAR WEIGHT: 202.3
BEILSTEIN REGISTRY No.: 1750791
EC No: 200-754-2
MDL No: MFCD00008215
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PRODUCT DESCRIPTION
Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells. Formed from spermidine through the addition of aminopropyl group to spermidine by spermine synthase. It is found as a polycation at physiological pH.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
DNA precipitation | Chromosome isolation | Crystallization of DNA
SPECIFICATIONS
SKU: 02152070-CF
Base Catalog Number: 152070
Alternate Names: Diaminopropyltetramethylenediamine; Gerontine; Musculamine; Neuridine; N,N-bis(aminopropyl)-1,4-butanediamine; 4,9-Diaza-1,12-dodecanediamine
Beilstein Registration No
: 1750791
Biochemical Physiological Actions
: Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Boiling Point
: 141-142°C at 0.5 mm Hg;
CAS
: #
71-44-3
EC No
: 200-754-2
Flash Point
: 110 °C / 230 °F (lit.)
Hazard Statements
: H314
MDL No
: MFCD00008215
Melting Point
: 28-30°C (Lit.)
Molecular Formula
: C10H26N4
Molecular Weight
: 202.3
pH
: 11-14 (0.5% aq soln)
PPE
: Eyeshields, Faceshields, full-face particle respirator ,Gloves, respirator cartridge, respirator filter
Purity
: =97%
RTECS No
: EJ7175000
Safety Symbol
: GHS05
Solubility
: Soluble in water (1% w/v), lower alcohol, chloroform; practically insoluble in ether, benzene, petroleum ether.
