Streptomycin sulfate,cell culture reagent, 5 g
Key Features and Details
SYNONYMS: Streptomycin Sesquisulfate; O-2-Deoxy-2-(methylamino)-a-L- glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl- (1->4)- N,N'- bis(aminoiminomethyl)-D-streptamine; Streptomycin A
CAS: # 3810-74-0
MOLECULAR FORMULA: 2C21H39N7O12 3H2SO4
MOLECULAR WEIGHT: 1457.4
BEILSTEIN REGISTRY No.: 3894995
EC No: 223-286-0
MDL No: MFCD00037023
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Streptomycin Sulfate is an aminoglucoside antibiotic in which streptidine is linked glycosidically to the disaccharide streptobiosamine. It is most active in a slightly alkaline medium. Inhibits initiation and causes misreading of rRNA in protein synthesis. Effective against gram-negative and gram-positive bacteria. About one-third of streptomycin in the circulation is bound to plasma proteins. About 30-90% of a dose is excreted unchanged in the urine in 24 hours. Application Notes Streptomycin, in combination with penicillin, is used in a standard antibiotic cocktail to prevent bacterial infection in cell culture. Streptomycin also is used as a pesticide, to combat the growth of bacteria, fungi, and algae. Streptomycin controls bacterial and fungal diseases of certain fruit, vegetables, seed, and ornamental crops, and it controls algae in ornamental ponds and aquaria. Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. Key Applications Antibiotic | Pesticide | Cell culture | Treatment of Tuberculosis, Plague
Base Catalog Number: 19454105
Alternate Names: Streptomycin Sesquisulfate; O-2-Deoxy-2-(methylamino)-a-L- glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl- (1->4)- N,N'- bis(aminoiminomethyl)-D-streptamine; Streptomycin A
Beilstein Registration No : 3894995
Biochemical Physiological Actions : Mode of Action: Inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome and casues miscoding: Binds to S12 protein of 30S ribosomal subunit causing the misreading or the inhibition of initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates. Inactivation: Streptomycin is inactivated by acids, alkalis, oxidizing and reducing agents, urea and other carbonyl-containing compounds, as well as by cysteine and other sulfhydryl-containing substances. Loss in potency was reported. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
CAS : # 3810-74-0
EC No : 223-286-0
Grade : Cell Culture
Hazard Statements : H302-H361
MDL No : MFCD00037023
Molecular Formula : 2C21H39N7O12 3H2SO4
Molecular Weight : 1457.4
PPE : Dust mask, Eyeshields, Faceshields, Gloves
RTECS No : WK4990000
Safety Symbol : GHS07, GHS08
Solubility : Soluble in aqueous solution (4% aq soln) (1 g/10 mL water - clear,colorless solution).
Specific Activity : =650 u/mg
Typical Working Concentration : Typically used at a concentration of 50-100 mg/liter.