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Sulfamethazine, sodium salt
Key Features and Details
Sulfamethazine Sodium Salt
SYNONYMS: 4-Amino-N-[4,6-dimethyl-2-pyrimidinyl]benzenesulfonamide
CAS: #
1981-58-4
MOLECULAR FORMULA: C12H13N4O2SNa
MOLECULAR WEIGHT: 300.312 g/mol
EC No: 217-840-0
MDL No: MFCD00068333
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PRODUCT DESCRIPTION
Sulfamethazine Sodium Salt
Application Notes
Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections. It is used in disposition and depletion kinetic studies. It is used to develop detection techniques for quantification in fluids such as cows milk, honey and swine urine.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SPECIFICATIONS
SKU: 02156709-CF
Base Catalog Number: 156709
Alternate Names: 4-Amino-N-[4,6-dimethyl-2-pyrimidinyl]benzenesulfonamide
Biochemical Physiological Actions
: Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
CAS
: #
1981-58-4
Density
: 1.4655 g/cu cm
EC No
: 217-840-0
Format
: Powder
Hazard Statements
: H302
MDL No
: MFCD00068333
Melting Point
: 176 deg C (also reported as mp 178-179 deg C; mp 198-199 deg C; mp 205-207 deg C)
Molecular Formula
: C12H13N4O2SNa
Molecular Weight
: 300.312 g/mol
RTECS No
: WO9300000
Safety Symbol
: GHS07
Solubility
: In water, 1.50X10+3 mg/L at 29 deg C and 1.92X10+3 mg/L at 37 deg C; solubility increases with increasing pH
Vapor Pressure
: 6.82X10-9 mm Hg at 25 deg C (est)
