Tetracycline, hydrochloride, cell culture reagent
Key Features and Details
Tetracycline Hydrochloride
SYNONYMS: Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a- octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin;, Achromycin V;, Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324
CAS: #
64-75-5
MOLECULAR FORMULA: C22H24N2O8·HCl
MOLECULAR WEIGHT: 480.898 g/mol
BEILSTEIN REGISTRY No.: 3844873
EC No: 200-593-8
MDL No: MFCD00078142
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PRODUCT DESCRIPTION
Tetracycline Hydrochloride
Application Notes
Tetracycline hydrochloride is used in tetracycline controlled gene expression systems (gene switches) such a the tet-on and tet-off systems.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Used in tetracycline controlled gene expression systems
SPECIFICATIONS
SKU: 02194542-CF
Base Catalog Number: 194542
Alternate Names: Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a- octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin;, Achromycin V;, Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324
Beilstein Registration No
: 3844873
Biochemical Physiological Actions
: Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Mode of Resistance: Loss of cell wall permeability.
CAS
: #
64-75-5
EC No
: 200-593-8
Extinction Coefficient
: EMm (220nm) = 13 (free base in 0.1 M HCl); EmM (268nm) = 18.04 (free base in 0.1 M HCl); EmM (355nm) = 13.32 (free base in 0.1 M HCl)(Lit.)
Format
: Powder
Grade
: Cell Culture
Hazard Statements
: H315-H319-H335
MDL No
: MFCD00078142
Melting Point
: 417° F (decomposes) (NTP, 1992)
Molecular Formula
: C22H24N2O8·HCl
Molecular Weight
: 480.898 g/mol
Optical Rotation: -239 ° to -258 ° (c=0.01, 0.1 N HCl)
pH
: 3.0-7.0 /saturated solution/
pKa
: pKa (50% aq DMF): 8.3, 10.2 (Lit.)
Potency
: =900 µg/mg
PPE
: Dust mask, Eyeshields, Gloves
Safety Symbol
: GHS07
Solubility
: 50 to 100 mg/mL at 72° F (NTP, 1992)
UV Visible Absorbance
: ? max (1N HCl) 219, 271, 357 ± 5 nm
