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Thrombin, high purity grade, =1500 NIH U/mg protein
Key Features and Details
Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B
Thrombin is prepared from fresh bovine plasma by an ion exchange method
Thrombin solution is clarified by centrifugation and filtration and then lyophilized
SYNONYMS: Factor IIa
CAS: #
2594047
EC No: 232-648-7
MDL No: MFCD00166053
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PRODUCT DESCRIPTION
Thrombin
Application Notes
a-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Research tool | Medicine | Surgery | Food Industry
SPECIFICATIONS
SKU: 02154163-CF
Base Catalog Number: 154163
Alternate Names: Factor IIa
Biochemical Physiological Actions
: Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.
CAS
: #
2594047
EC No
: 232-648-7
Grade
: High Purity
Hazard Statements
: H315-H319-H334-H335
MDL No
: MFCD00166053
Purity
: Grade
High
RTECS No
: XO8950000
Safety Symbol
: GHS07, GHS08
Source
: Bovine
Specific Activity
: =1500 NIH u/mg protein
Unit Definition
: The unit defined by the U.S. standard and is approximately equal to the stated unitage. A U.S. unit is defined as the amount required to clot 1 mL of standardized fibrinogen solution in 15 seconds. Approximately 2 U.S. units are required to clot 1 ml of oxalated human plasma in the same period of time. U.S units = NIH units.
