Tobramycin, USP
Key Features and Details
Tobramycin
SYNONYMS: Nebramycin Factor 6; O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1?6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1?4)]-2-deoxy-D-streptamine
CAS: #
32986-56-4
MOLECULAR FORMULA: C18H37N5O9
MOLECULAR WEIGHT: 467.52 g/mol
BEILSTEIN REGISTRY No.: 1357507
EC No: 251-322-5
MDL No: MFCD00077885
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PRODUCT DESCRIPTION
Tobramycin
Application Notes
Tobramycin has been used:• to study the effect of tobramycin on bacteriophage infected biofilms• to study the effects of antibiotics on Pseudomonas aeruginosa strain• as a comparator antibiotic
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
SPECIFICATIONS
SKU: 02199697-CF
Base Catalog Number: 199697
Alternate Names: Nebramycin Factor 6; O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1?6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1?4)]-2-deoxy-D-streptamine
Beilstein Registration No
: 1357507
Biochemical Physiological Actions
: Tobramycin is an aminoglycoside. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.
CAS
: #
32986-56-4
EC No
: 251-322-5
Format
: Powder
Grade
: USP
Hazard Statements
: H315+H319+H317+H335
MDL No
: MFCD00077885
Molecular Formula
: C18H37N5O9
Molecular Weight
: 467.52 g/mol
pH
: Basic substance
Potency
: =900 µg/mg
Safety Symbol
: GHS08, GHS07
Solubility
: Water Solubility1000 mg/ml
Vapor Pressure
: 2.37X10-21 mm Hg at 25 deg C (est)
