Trimethoprim
Key Features and Details
Trimethoprim
SYNONYMS: 2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine
CAS: #
738-70-5
MOLECULAR FORMULA: C14H18N4O3
MOLECULAR WEIGHT: 290.323 g/mol
BEILSTEIN REGISTRY No.: 625127
EC No: 212-006-2
MDL No: MFCD00036761
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PRODUCT DESCRIPTION
Trimethoprim
Application Notes
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibacterial
SPECIFICATIONS
SKU: 02195527-CF
Base Catalog Number: 195527
Alternate Names: 2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine
Beilstein Registration No
: 625127
Biochemical Physiological Actions
: The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
CAS
: #
738-70-5
EC No
: 212-006-2
MDL No
: MFCD00036761
Melting Point
: 390 to 397° F (NTP, 1992)
Molecular Formula
: C14H18N4O3
Molecular Weight
: 290.323 g/mol
PPE
: Eyeshields, Gloves, respirator filter
RTECS No
: UV8225000
