Nucleolus Bright Red

Description

A Nucleolus is one of the structures forming a nucleus and becoming the starting point of the ribosomal biogenesis. There are many ribosomal RNA (rRNA) in the nucleolus and transcription of rRNA and processing are carried out. Whereas the morphological change of nucleolus is known as one of the indicators of cancer diagnosis, there have been some scientific reports describing the relation between nucleolus and DNA damage, autophagy, virus infection, and cellular senescence.

Nucleolus Bright dyes are small molecules that bind to RNA in the nucleolus to emit fluorescence. The nucleolus can be observed without any washing steps after staining with Nucleolus Bright dyes. Nucleolus Bright reacts to RNAs present besides the nucleolus, but it shows strong fluorescence in the nucleolus, which is the site of rRNA production.